“Cannibalism is one thing, but increasing longevity by eating human flesh….” – The X-Files
I’m not going to tell an AARP® joke: they’re all pretty old.
David Sinclair isn’t a medical doctor, but he’s got a laboratory at Harvard© Medical School. That’s the real Harvard®, not the Haarvard™ School of Witchcraft and Legal Studies I started a few years ago. It was accredited by Madame Kim’s Korean Restaurant (located under the Vance’s Bowl-a-Rama in Scranton, Pennsylvania. One of my students turned me into a newt.
But I got better. (R.I.P. Terry Jones)
Anyway, Sinclair actually teaches at the real Harvard© and not my scam internet school beloved privately held institution of learning. Dr. Sinclair is not a medical doctor, but is instead a PhD, which is troubling to me now – there was no real reason he should have checked me for breast cancer. And do most of those checks really take an hour? But as I watched a video of him chatting about the future, it struck me: he looks just like Christian Slater.
He may look a lot like Christian Slater, but the good Doctor Sinclair looks sheltered. I mean, who doesn’t have a three day cocaine, heroin, and tequila binge resulting in assault on a police officer and three months in the slammer? Oh, only Christian?
Anyway, Dr. Sinclair is mainly interested in longevity. When I say mainly, he’s done research on longevity since the 1990’s. Currently, he feels he has the reason that we age: as we get older, our cells forget what it is that they should be doing.
What, a cell can forget? How does that work?
DNA is a long strand in a cell. How long? If you stretched out a DNA strand, it would be (by most calculations I’ve seen on the Internet) over six feet long. Obviously, just like Tom Cruise, your cells aren’t six feet long. Therefore, the DNA has to be wound up to fit inside a cell.
Remember, sharing DNA with those you share DNA with can have consequences. Just ask the governor of Virginia!
In a really neat trick, it’s not the just the DNA that determines what a cell does, it’s the way that the DNA is wound up in little knots to fit in the cell. Since every cell has the same DNA, it’s not the DNA that determines what a cell does: it’s how the DNA is coiled in a cell that defines what that cell does. That available information on the coiled up bits of DNA is what makes a cell a nerve cell. Or a skin cell. Or, for you lucky people, a hair follicle.
Wait, that’s not true. I have hair. It’s just in my ears. What gives?
The answer is simple. The skin cells had the DNA originally coiled up to be skin cells. But after a while, the winding became . . . not as good in a few of them, so skin cells decided that they wanted to start a hobby: making hair. So places that didn’t have hair in my 20’s, now have hair. Just not where I wanted it – sure I feel the wind blowing through my hair still, but now it’s my back hair.
Fun Fact: Lloyd’s of London® will not insure the Kardashian family against Velcro©.
Sinclair thinks that part of the key to having humans live to be 170 or longer is in resetting that mechanism so the DNA coils up correctly in the cell. He suggests the reset might be possible, but it involves viruses, PEZ®, and painters scaffolding. I kid. Except for the viruses. Dr. Sinclair has several theories on how this reset can be done, and, yes, one of them includes a virus. Some of them involve drugs or supplements. I’m not planning on selling supplements here (though I hear that can be lucrative if you’re in talk radio) but you can look up his advice on supplements. Remember, he’s not a doctor, at least not the medical kind.
But he does have some advice that’s certainly (mostly) free to pursue, and probably harmless:
- Be cold. Apparently The Mrs. is right that the air conditioning should be set at 54°F in the summer, since being cold appears to activate mechanisms that reduce inflammation. We also keep Stately Wilder Manor cold in winter. Sometimes when your author is writing in winter I actually rub two verbs together to keep warm.
- Be hot. Not like supermodel hot, but actually physically warm. If you’re both, you probably get bonus points. Saunas have been documented to lower blood pressure and much lower death rates. I don’t have a sauna, but I have a hot tub (I keep it warm by burning $100 bills) and I’m in it 4 or 5 times a week. I can’t keep it at 175°F like the Finnish people do, but I imagine that 104°F is close enough.
- Work out. This isn’t news, since this has been done to get people healthy since at least the time of the Roman Empire. But it appears that higher intensity workouts, stressing the body increases the body’s aging defenses. Sinclair suggests high intensity interval training.
- Fast. This actually saves you money, since you’re not spending money on food when you do it. I wrote a bit about fasting here (The Last Weight Loss Advice You’ll Ever Need, Plus a Girl in a Bikini Drinking Water) and think it’s something that I think would benefit most people. Fasting appears to lower blood pressure, blood sugar, cholesterol, and lower inflammation. The downside? You’re fasting.
- Don’t eat so much protein. This is the tough one. Sinclair noted that too much protein causes lower levels of NAD – heh hehe heh heh, he said “NAD” – and NAD is a nucleotide called “nicotinamide adenine dinucleotide” that decreases as you age. NAD is one of Sinclair’s main keys to aging. But I like steak. I’m not sure that I want to live to 170 without steak. Plus, if I’m not supposed to eat carbs, and now not supposed to eat protein, what’s left? Sticks of butter covered in grass clippings?
Not only do you have to set your cake on fire, you can’t eat it.
Again, those are (mostly) free to do, and in some cases put money back in your pocket.
Observationally, the things on the list are things that suck. We want to be at comfortable temperatures, sitting on the couch with chocolate and steak smeared faces. We want to live in malls, comfortable and cocooned against all discomfort. But longer life appears to be triggered by being uncomfortable. Since you’re not happy when you’re uncomfortable, that means time goes more slowly. So not only do you live longer, it also feels like you’re living longer. You might live to 170, but it feels like 1,700 years.
But what about the other things that kill you besides growing old?
In the past week, it looks like (fingers crossed) there’s a breakthrough against cancer. Despite cancer being utterly curable in mice for, oh, decades, this particular cure uses the body’s own immune system to eat the cancer cells. I’m betting this has about 1 chance in 10 of working, but that’s better news than any cancer news in recent memory. Ruth Bader Ginsburg seems to not need this, though.
Remember, the Supreme Court is just regular court with sour cream and tomato.
If we cure cancer and aging, we’re home free, right?
Well, there are still things like dementia, liver failure, kidney failure, diabetes, and heart disease. Certainly following Dr. Sinclair’s suggestions will help with some of these, but it’s not likely it will help with all of them. I’m not trying to be pessimistic here, but solving all of the body’s problems isn’t as easy as jumping in the hot tub with a supermodel or avoiding steak.
For a long life to be worth it, it should be one where I don’t live from year 70 to year 140 as a rambling, dementia cursed old man. And Dr. Sinclair’s dad, who is now 80, has been following Sinclair’s advice and is still quite active.
Or was it Dr. Sinclair’s advice after all? It could have been Christian Slater. And always remember my motto:
Shoot now, ask Christian Slater.
Here’s a video of Dr. Sinclair, if you want to check either my facts or the Christian Slater resemblance.